Pneumovax 23 Vaccine is utilized for prevention of diseases cautilized by pneumococcal bacteria such as pneumonia, meningitis, ear infections, and blood infections. Pneumovax 23 Vaccine is usually given as an injection into the muscle of the upper arm by a doctor or a nurse. It should not be self-administered. Only one dose is needed for most people. A booster dose can be given 5 years after the first dose. Some common side effects of this vaccine include injection site reactions (such as pain, swelling, redness), headache, weakness, tiredness, and muscle pain. If these side effects persist or get worse, let the doctor know. The doctor may help with ways to reduce or prevent these symptoms.